Mixed T cell receptor dimers harbor potentially harmful neoreactivity.

AB T-Cell Receptor Engineered ;D T Cells Mediate Effective Antileukemic Reactivity

Retroviral transfer of T-cell receptors (TCR) to peripheral blood–derived T cells generates large numbers of T cells with the same antigen specificity, potentially useful for adoptive immunotherapy. One drawback of this procedure is the formation of mixed TCR dimers with unknown specificities due to pairing of endogenous and introduced TCR chains. We investigated whether ;D T cells can be an al...

T Cell Receptor Transfer to T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo

HLA-G in human early pregnancy: control of uterine immune cell activation and likely vascular remodeling.

Despite a number of controversies, the functional importance of human leukocyte antigen G (HLA-G) in early human pregnancy is now sustained by a large amount of sound data. Membrane-bound and soluble HLA-G isoforms, either as β2-microglobulin-free or -associated as monomers or dimers, are expressed by different trophoblast subpopulations, the only fetal-derived cells that are directly in contac...

Crosslinking snapshots of bacterial chemoreceptor squads.

The team signaling model for bacterial chemoreceptors proposes that receptor dimers of different detection specificities form mixed trimers of dimers. These receptor "squads" then recruit the cytoplasmic signaling proteins CheA and CheW to form ternary signaling teams, which typically cluster at the poles of the cell. We devised cysteine-directed in vivo crosslinking approaches to ask whether m...

Morphology and Phylogeny of Scrippsiella trochoidea (Dinophyceae) a potentially harmful bloom forming species isolated from the sediments of Iran’s south coast

Phytoplankton cells and resting cysts of the species Scrippsiella trochoidea are regular and dominant components of the dinoflagellate flora of coastal marine waters and sediments around the world. This species is a common harmful bloom forming species in coastal waters. In this study, for the first time cyst of S. trochoidea were isolated from the sediments of southeast coast of Iran. Five str...